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I have been using Zoho http://www.zoho.com. It works pretty well for me, it is on-line and free.

Microsoft Office Project Standard has a 'multiple level undo' feature that lets you experiment with different scenarios.

I use BaseCamp to manage my company and employees and projects as well. However from the original post I was 'assuming' that he was looking for a relational database type of project management.

There is also something called @task. Complicated and expensive to say the least.

We built our own custom system which accomplished all of those things and more, however Microsoft Project is a really good tool also.

You might want to consider looking at BillQuick (BQE Software). Works exceptionally well for many of my clients.
-M

For me, MS Project is too complex for planning simple projects, too feeble for planning major projects, and too proprietary for planning projects where any of the information has to be ported to or from multiple platforms and applications (which would be important to you, it seems). Even so, I have about 120 clients for whom it's the in-house "standard" project planning tool. As a tracking tool, I don't much care for MS Project at all -- it doesn't have the design or functionality to facilitate the type of resource tracking that's required in a typical project environment (and I think you'd have the same trouble using it to manage the multiple client scenario you describe). Most of my clients had to have custom interfaces written to get planning data out of Project and into some other decent tracking software to make that aspect manageable. (That dual-tool approach can get expensive.)

Understood . . . it's the "multiple resources collaborating on multiple projects" part of fakeblond's situation that concerned me. MS Project can do it -- it's just the way it does it that makes it a real pain to track time, material, and/or resources through the multiple linked project infrastructure (and all that has to be set up right from the very start).